[ad_1]

The bacteria that reside on and within our bodies are known to have a significant influence on our health. New research suggests wiping out the gut microbiota could improve heart functioning and potentially slow the cardiac damage that occurs with heart failure.

The research is based on the idea that microbes living in the gastrointestinal tract affect heart failure by increasing the production of T cells, a type of immune cell. Researchers found mice with induced heart failure fared better if they were treated with antibiotics for five weeks, essentially sterilizing the gut.

“Our lab studies how the gut talks to the heart through T cells,” said Francisco J. Carrillo-Salinas, PhD, a postdoctoral scholar at Tufts University who conducted the research. “Given that the gut is the body’s largest reservoir of T cells and microbes, by modulating the microbiota we could modulate T cell activation and changes in the heart that lead to heart failure.”

Carrillo-Salinas will present the research at the American Society for Investigative Pathology annual meeting during the 2018 Experimental Biology meeting, held April 21-25 in San Diego.

Heart failure is a condition in which the heart cannot pump enough blood to meet the body’s needs. Nearly 6 million Americans have heart failure, and about half of people diagnosed with heart failure die within five years.

Carrillo-Salinas’ group has previously shown that T cells infiltrate the heart in patients with heart failure. Inflammation, which is a consequence of the immune response, also is known to play important roles in heart disease.

Other research has suggested disruption of the gut microbiota can affect cardiovascular health. The gut microbiota can be altered by dietary changes or the use of antibiotics.

To decipher how changes in the gut microbiota affect T cell activity in the heart, the researchers examined markers of cardiovascular functioning and proteins relevant to immune activity in four groups of mice. Half of the mice received a cocktail of broad-spectrum antibiotics for five weeks that completely depleted bacteria from the gut. Half of those receiving the antibiotics and half of those not receiving the antibiotics also underwent a procedure to modify the aorta in a way that mimics the effects of heart failure in humans.

Among mice with induced heart failure, those that received antibiotics showed significantly better heart pumping ability and less damage to the heart tissue compared to those that did not receive antibiotics.

“Because complete sterilization of the gut has proven to ameliorate some experimental models of T cell mediated diseases, our results were in agreement with our initial hypothesis,” said Carrillo-Salinas. “The fact that we see fully preserved heart function is surprising, and I am looking forward to exciting new data on what happens in the heart once different bacteria recolonize the gut.”

The results suggest that T cells are activated in the lymph nodes located nearest the heart, move into the heart and then contribute to heart failure progression by releasing signaling proteins known as cytokines and inducing the heart to become enlarged and form scar tissue. All of these changes were prevented in the mice that received antibiotics.

“Understanding how the gut microbiota directly regulates the function of distant organs such as the heart will shed new light into potential new therapeutic approaches in patients recently diagnosed with heart failure to prevent progression,” said Carrillo-Salinas. “Our results demonstrate that gut microbiota depletion prevents cardiac dysfunction and set the stage for future studies that will determine which components of the microbiota are responsible for heart failure progression.”

Story Source:

Materials provided by Experimental Biology 2018. Note: Content may be edited for style and length.

[ad_2]

Source link

Agribusiness Information

165 COMMENTS

  1. Great post. I was checking constantly this blog and I’m impressed!
    Very useful info specially the last part 🙂 I care for such info
    much. I was seeking this particular information for a
    very long time. Thank you and best of luck.

  2. I just like the valuable information you supply on your
    articles. I’ll bookmark your weblog and take a look at once more here regularly.

    I am quite sure I will learn many new stuff proper here!

    Good luck for the following!

  3. Great post. I was checking continuously this blog and I am impressed!
    Extremely useful information particularly the last part :
    ) I care for such information much. I was seeking this certain info for a very long
    time. Thank you and best of luck.

  4. Howdy! This article couldn’t be written any better!
    Looking through this article reminds me of my previous roommate!
    He continually kept talking about this. I am going to forward this information to him.
    Pretty sure he’ll have a great read. Thank you for sharing!

  5. Its like you read my mind! You appear to know so
    much about this, like you wrote the book in it or something.
    I think that you can do with some pics to drive
    the message home a bit, but other than that, this is magnificent blog.
    A fantastic read. I will definitely be back.

  6. I am extremely impressed with your writing skills as well as with the layout on your weblog.
    Is this a paid theme or did you modify it yourself? Anyway keep
    up the excellent quality writing, it is rare to see a nice blog like this one these days.

  7. I will immediately grab your rss feed as I can’t find your e-mail
    subscription hyperlink or newsletter service. Do you’ve any?
    Please allow me realize so that I could subscribe. Thanks.

  8. Definitely believe that which you stated. Your favorite
    reason appeared to be on the web the easiest thing to be aware of.
    I say to you, I certainly get irked while people think about worries that they plainly don’t
    know about. You managed to hit the nail upon the top and also defined
    out the whole thing without having side effect , people could take a signal.
    Will likely be back to get more. Thanks

  9. Thank you for the auspicious writeup. It in fact was a
    amusement account it. Look advanced to more added agreeable from you!

    By the way, how can we communicate?

  10. Please let me know if you’re looking for a writer for your blog.
    You have some really good posts and I believe I would be a good asset.
    If you ever want to take some of the load off, I’d absolutely
    love to write some content for your blog in exchange for a link back to mine.
    Please shoot me an e-mail if interested. Kudos!

  11. Hello great website! Does running a blog similar to this take a massive amount work?

    I have very little knowledge of coding but I had been hoping to start my own blog in the near future.
    Anyways, if you have any ideas or techniques for new blog owners
    please share. I understand this is off topic but I simply needed to ask.

    Appreciate it!

  12. This is really interesting, You are a very skilled blogger.
    I have joined your feed and look forward to seeking more of
    your excellent post. Also, I’ve shared your site in my social networks!

  13. Please let me know if you’re looking for a author for your site.

    You have some really great posts and I think I would be
    a good asset. If you ever want to take some of the load off, I’d
    love to write some material for your blog in exchange for a
    link back to mine. Please blast me an email if interested.
    Kudos!

  14. Hey there! I could have sworn I’ve been to this website before but after browsing through some
    of the post I realized it’s new to me. Anyhow, I’m definitely glad I found it and I’ll be bookmarking and checking back frequently!

  15. Nice blog right here! Additionally your website a lot up very fast!
    What host are you using? Can I get your associate link on your host?
    I want my site loaded up as quickly as yours lol

  16. Hello would you mind letting me know which hosting company
    you’re utilizing? I’ve loaded your blog in 3 different internet browsers and I must say
    this blog loads a lot faster then most. Can you suggest a good internet hosting provider at a honest price?

    Thanks a lot, I appreciate it!

  17. It is the best time to make some plans for the long run and
    it’s time to be happy. I have read this put up and if I may just I want to suggest you
    some attention-grabbing issues or tips. Maybe you
    could write subsequent articles referring to this article.

    I want to learn even more things about it!

  18. My brother recommended I may like this website.
    He was totally right. This put up actually made my day.
    You cann’t consider just how much time I had spent for
    this information! Thanks!

  19. Pretty component to content. I just stumbled upon your website
    and in accession capital to assert that I acquire in fact loved account your
    weblog posts. Anyway I’ll be subscribing on your augment and even I achievement you
    access constantly quickly.

  20. Hi there, I found your site by the use of Google at the same time as searching for a similar matter, your site got here up, it looks
    great. I’ve bookmarked it in my google bookmarks.

    Hello there, simply changed into alert to your weblog thru Google, and found that it is really informative.
    I’m going to watch out for brussels. I will appreciate
    in the event you proceed this in future. A lot of other people will likely be benefited out of your
    writing. Cheers!

  21. We are a group of volunteers and opening a new scheme in our community.

    Your website provided us with helpful information to work on. You’ve done
    a formidable process and our entire neighborhood might be
    grateful to you.

  22. I’m really enjoying the theme/design of your weblog. Do
    you ever run into any internet browser compatibility issues?

    A number of my blog readers have complained about my
    website not operating correctly in Explorer but looks great in Firefox.
    Do you have any ideas to help fix this problem?

  23. This design is spectacular! You certainly know how to keep
    a reader entertained. Between your wit and your videos, I was
    almost moved to start my own blog (well, almost…HaHa!) Fantastic job.
    I really loved what you had to say, and more than that,
    how you presented it. Too cool!

  24. A person necessarily lend a hand to make significantly articles I might state.
    This is the very first time I frequented your website page and so far?
    I surprised with the analysis you made to make this actual submit
    incredible. Excellent task!

  25. Thanks on your marvelous posting! I certainly enjoyed
    reading it, you are a great author.I will make sure to bookmark
    your blog and will eventually come back sometime soon. I want to encourage one to
    continue your great job, have a nice holiday weekend!

  26. Link exchange is nothing else but it is only placing the other person’s webpage link on your page at appropriate place
    and other person will also do similar in favor of you.

  27. Hey There. I found your blog using msn. This is a very well written article.
    I’ll be sure to bookmark it and come back to read more of your useful information. Thanks for the post.
    I’ll definitely comeback.

  28. I used to be recommended this blog by way of my cousin. I am now not certain whether or not this post is written by means of him as no one else recognise such unique approximately my trouble.
    You are incredible! Thanks!

  29. Write more, thats all I have to say. Literally,
    it seems as though you relied on the video to
    make your point. You clearly know what youre
    talking about, why waste your intelligence on just posting videos
    to your blog when you could be giving us something enlightening to read?

  30. With havin so much content and articles do you ever
    run into any problems of plagorism or copyright violation? My blog has
    a lot of unique content I’ve either authored myself or outsourced but it looks like a lot of it is popping it up all over the internet without my authorization. Do you know any ways to help
    protect against content from being stolen? I’d really appreciate it.

  31. Thank you for the good writeup. It in reality was a amusement account it.
    Glance complex to more delivered agreeable from you!

    By the way, how could we keep up a correspondence?

  32. Thanks for one’s marvelous posting! I definitely enjoyed reading it, you are a great author.
    I will make certain to bookmark your blog and definitely
    will come back in the foreseeable future. I want to encourage you to ultimately continue your great job, have a
    nice afternoon!

  33. Hi there! I know this is somewhat off topic but I was wondering which blog platform are you
    using for this site? I’m getting sick and tired of WordPress because I’ve had issues with hackers and I’m looking at options
    for another platform. I would be great if you could point me in the direction of a good platform.

  34. I’ll immediately grab your rss as I can’t in finding your
    email subscription hyperlink or e-newsletter service. Do you have any?
    Please allow me understand so that I could subscribe.
    Thanks.

  35. Thanks , I have recently been looking for information approximately
    this subject for ages and yours is the greatest I’ve found out till now.
    But, what concerning the conclusion? Are you certain in regards to the supply?

  36. I know this if off topic but I’m looking into starting my own weblog and was curious
    what all is required to get set up? I’m assuming having a blog like yours would cost a pretty penny?
    I’m not very web smart so I’m not 100% positive.
    Any recommendations or advice would be greatly appreciated.
    Cheers

  37. Hello there, I think your site could be having browser compatibility issues.
    Whenever I look at your web site in Safari, it looks fine however, when opening in I.E.,
    it’s got some overlapping issues. I merely wanted to provide you with a quick heads
    up! Apart from that, excellent site!

  38. Wonderful work! This is the kind of information that should
    be shared across the internet. Disgrace on the seek engines for no longer positioning this post upper!
    Come on over and talk over with my site . Thank you =)

  39. Hi there! This blog post could not be written any better!

    Looking through this post reminds me of my previous roommate!

    He always kept preaching about this. I’ll forward this post
    to him. Pretty sure he’ll have a very good read. I appreciate
    you for sharing!

  40. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my
    newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have
    some experience with something like this. Please let me know if you run into anything.

    I truly enjoy reading your blog and I look forward
    to your new updates.

  41. You have made some really good points there. I looked on the net for more
    information about the issue and found most individuals
    will go along with your views on this web site.

  42. I was curious if you ever thought of changing the page layout of your site?

    Its very well written; I love what youve got to say.
    But maybe you could a little more in the way of content
    so people could connect with it better. Youve got an awful lot of text for only having 1 or 2 images.
    Maybe you could space it out better?

  43. Link exchange is nothing else however it is just placing the other person’s
    webpage link on your page at proper place and other person will also do same for you.

  44. Hey there this is kinda of off topic but I was wondering if blogs use
    WYSIWYG editors or if you have to manually code with HTML.

    I’m starting a blog soon but have no coding experience so I wanted to get guidance from someone with experience.
    Any help would be enormously appreciated!

  45. Wow that was strange. I just wrote an extremely long comment
    but after I clicked submit my comment didn’t show up.
    Grrrr… well I’m not writing all that over again. Regardless, just wanted to say fantastic blog!

  46. Hey! I know this is somewhat off topic but I was wondering
    which blog platform are you using for this site? I’m getting fed up
    of WordPress because I’ve had issues with hackers and I’m looking at alternatives for another platform.
    I would be great if you could point me in the direction of a good platform.

  47. Hey there just wanted to give you a brief heads up and let you know a few
    of the pictures aren’t loading correctly. I’m not sure why but I think its a linking issue.
    I’ve tried it in two different browsers and both show the same results.

  48. We absolutely love your blog and find a lot of your post’s to be exactly what I’m looking
    for. Would you offer guest writers to write content for you personally?
    I wouldn’t mind publishing a post or elaborating on most of the subjects you write concerning
    here. Again, awesome weblog!

  49. Good day! I could have sworn I’ve been to this site before but after
    reading through some of the post I realized it’s new to me.

    Anyhow, I’m definitely happy I found it and I’ll be bookmarking and checking back often!

  50. Hey there just wanted to give you a quick heads up.
    The words in your post seem to be running off the screen in Safari.
    I’m not sure if this is a formatting issue or
    something to do with browser compatibility but I figured I’d post to let
    you know. The layout look great though! Hope you get the problem solved soon. Cheers

  51. My brother recommended I might like this web site. He was totally
    right. This post truly made my day. You cann’t imagine simply how much time I had
    spent for this info! Thanks!

  52. Howdy just wanted to give you a brief heads up and let you know a
    few of the images aren’t loading properly. I’m not sure why but
    I think its a linking issue. I’ve tried it in two
    different internet browsers and both show the same outcome.

  53. Hi! I could have sworn I’ve been to this website before
    but after checking through some of the post I realized it’s
    new to me. Anyways, I’m definitely delighted I found it and
    I’ll be book-marking and checking back often!

  54. Please let me know if you’re looking for a author for your site.
    You have some really great posts and I believe I would be a good asset.
    If you ever want to take some of the load off, I’d absolutely love to write some material for
    your blog in exchange for a link back to mine. Please shoot me an e-mail if interested.

    Kudos!

  55. I’m curious to find out what blog platform you are working with?
    I’m experiencing some minor security issues with my latest
    website and I would like to find something more risk-free.
    Do you have any suggestions?

  56. I’m really loving the theme/design of your weblog. Do you ever run into any
    internet browser compatibility issues? A handful of my blog audience
    have complained about my site not operating correctly in Explorer but looks
    great in Opera. Do you have any suggestions to help fix this problem?

  57. Its like you learn my mind! You seem to understand a lot approximately this, such
    as you wrote the ebook in it or something.
    I think that you just could do with a few p.c. to force the message house
    a bit, however other than that, that is fantastic blog.
    An excellent read. I’ll definitely be back.

  58. I do believe all of the ideas you have presented for your post.
    They are very convincing and will certainly work. Still, the posts
    are very quick for starters. Could you please prolong them a little from next time?

    Thanks for the post.

  59. Hi there would you mind sharing which blog platform
    you’re using? I’m planning to start my own blog
    in the near future but I’m having a tough time deciding between BlogEngine/Wordpress/B2evolution and Drupal.

    The reason I ask is because your design seems different then most blogs and I’m looking for something
    unique. P.S Sorry for getting off-topic but I
    had to ask!

  60. I loved as much as you will receive carried out right here.
    The sketch is tasteful, your authored material stylish.
    nonetheless, you command get got an edginess over that you wish be delivering the following.
    unwell unquestionably come more formerly again as exactly the same
    nearly very often inside case you shield this hike.

  61. I like the helpful info you provide in your articles.
    I’ll bookmark your weblog and check again here
    frequently. I am quite sure I’ll learn many new
    stuff right here! Good luck for the next!

  62. Hi, I do believe this is an excellent site. I stumbledupon it
    😉 I’m going to come back once again since I bookmarked it.
    Money and freedom is the best way to change, may you
    be rich and continue to help other people.

  63. Good day! I could have sworn I’ve visited this website before but after going through a few of the posts
    I realized it’s new to me. Regardless, I’m certainly happy I found
    it and I’ll be bookmarking it and checking back often!

  64. Hey there just wanted to give you a quick heads up. The words in your content seem
    to be running off the screen in Ie. I’m not sure if this is a formatting issue or something to do
    with internet browser compatibility but I thought I’d post to let you know.

    The design look great though! Hope you get the problem fixed soon. Kudos

  65. Great beat ! I would like to apprentice while
    you amend your website, how could i subscribe for a blog website?
    The account aided me a acceptable deal. I had been tiny bit acquainted of this your broadcast offered bright clear concept

  66. Hey! I just wanted to ask if you ever have any issues
    with hackers? My last blog (wordpress) was
    hacked and I ended up losing several weeks of hard work due to no back up.
    Do you have any methods to stop hackers?

  67. Hmm it looks like your blog ate my first comment (it was
    super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog.
    I as well am an aspiring blog writer but I’m still new to the
    whole thing. Do you have any points for rookie blog writers?
    I’d genuinely appreciate it.

  68. I’m amazed, I must say. Rarely do I encounter a blog that’s both educative and entertaining, and let me tell you,
    you have hit the nail on the head. The problem is
    something that too few people are speaking intelligently about.

    I am very happy I came across this during my search for something concerning
    this.

  69. I do believe all of the ideas you’ve offered in your post.
    They’re very convincing and can definitely work.
    Still, the posts are too quick for newbies. May you please prolong them a bit from subsequent time?
    Thanks for the post.

  70. hello there and thank you for your info – I’ve definitely picked up something new
    from right here. I did however expertise some technical
    points using this website, as I experienced to reload the website
    many times previous to I could get it to load properly.

    I had been wondering if your hosting is OK?
    Not that I am complaining, but sluggish loading instances times will very
    frequently affect your placement in google and can damage your quality score if ads and marketing with Adwords.
    Well I am adding this RSS to my email and can look
    out for a lot more of your respective interesting content.
    Ensure that you update this again soon.

  71. Today, I went to the beachfront with my children. I found a sea shell and gave it to
    my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed
    the shell to her ear and screamed. There was a hermit crab
    inside and it pinched her ear. She never wants to go back!
    LoL I know this is totally off topic but I had to tell someone!

  72. I’m really enjoying the design and layout of your website.

    It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did
    you hire out a developer to create your theme? Superb work!

LEAVE A REPLY

Please enter your comment!
Please enter your name here