[ad_1]

While most fat cells in the human body store energy, everyone has a small subset of brown fat cells that do the opposite — burn energy and generate heat. Now, Salk researchers have discovered how the molecule ERRγ gives this “healthier” brown fat its energy-expending identity, making those cells ready to warm you up when you step into the cold, and potentially offering a new therapeutic target for diseases related to obesity. The paper appears in Cell Reports on March 13, 2018.

“This not only advances our understanding of how the body responds to cold, but could lead to new ways to control the amount of brown fat in the body, which has links to obesity, diabetes and fatty liver disease,” says senior author Ronald Evans, Howard Hughes Medical Institute investigator and holder of Salk’s March of Dimes Chair in Molecular and Developmental Biology.

Until about a decade ago, scientists thought that only babies — who can’t yet shiver to warm up — had brown fat in their bodies. Studies have since shown that adults also have brown fat, albeit at much lower levels, and people with lower body mass indexes (BMIs) tend to have more of it. At a cellular level, brown fat cells are crammed full of energy-generating mitochondria, which give the cells their brown color.

In the new work, Evans’ group focused on estrogen-related receptor gamma (ERRγ), a gene that is active at high levels in brown fat cells.

“We were interested in what maintains brown fat, even when we’re not exposed to cold all the time,” says Maryam Ahmadian, a Salk research associate and first author of the new paper.

The team found that brown fat cells express the ERRγ gene all the time (not just in response to cold) and that white fat cells do not express the gene at all. And by studying mice lacking the gene for ERRγ (and therefore unable to make the ERRy molecule), the team observed that all brown fat cells resembled white cells in these mice. Additionally, the animals were unable to maintain their body temperature when exposed to cold temperatures. While 80 percent of normal mice are able to handle a temperature drop, all mice lacking ERRγ did not tolerate the cold. However, there was no difference in the metabolism or weight of the mice. Together, the experiments reveal that ERRγ is key to helping brown fat maintain its identity and its ability to respond to cold.

Since the ERRγ gene codes for a protein that can travel into the cell nucleus and directly control the expression of other genes, the team also probed which genes were mediated by ERRγ in brown fat cells. They pinpointed a number of genes already known to be important in brown fat, but which hadn’t been specifically linked to ERRγ in the past.

“We uncovered the factors that are both involved in protection against the cold and underpin brown fat identity,” says Michael Downes, a Salk senior scientist and co-senior author of the paper.

The group is planning future studies that look at the effect of activating ERRγ in white fat cells — which they suspect could make some white fat resemble brown fat, and potentially help treat obesity and diabetes. They also want to study whether the role of ERRγ in the brown fat of humans is the same as what they’ve observed in mice.

Story Source:

Materials provided by Salk Institute. Note: Content may be edited for style and length.

[ad_2]

Source link

Agribusiness Information

RELATED ARTICLESMORE FROM AUTHOR

428 COMMENTS

  1. What’s up i am kavin, its my first time to commenting anywhere, when i read
    this piece of writing i thought i could also create comment due
    to this brilliant piece of writing.

  2. I’m not sure where you’re getting your info, but good topic.
    I needs to spend some time learning much more or understanding more.
    Thanks for fantastic information I was looking for this information for my
    mission.

  10. Howdy! I know this is somewhat off topic but
    I was wondering which blog platform are you using for this site?
    I’m getting sick and tired of WordPress because I’ve had
    problems with hackers and I’m looking at options for another platform.
    I would be awesome if you could point me in the direction of a good platform.

  15. When I initially commented I clicked the “Notify me when new comments are added” checkbox and now
    each time a comment is added I get four emails with
    the same comment. Is there any way you can remove people from that service?
    Thank you!

  17. Write more, thats all I have to say. Literally, it
    seems as though you relied on the video to make your point.
    You obviously know what youre talking about, why throw away your intelligence on just posting videos to your
    blog when you could be giving us something enlightening to
    read?

  25. Wonderful site you have here but I was curious if you knew of any forums that cover
    the same topics discussed in this article? I’d really
    love to be a part of group where I can get responses from other experienced individuals that share the same interest.
    If you have any recommendations, please let me know.

    Bless you!

  27. I was suggested this website through my cousin. I’m no longer certain whether this put up is written by him as nobody else understand such particular approximately my problem.
    You are amazing! Thank you!

  30. I feel that is one of the most significant info for me. And i am glad reading your article.
    But should commentary on some basic things, The site taste is ideal,
    the articles is actually excellent : D. Good process, cheers

  36. I feel that is one of the most significant information for me.
    And i am satisfied studying your article. However want to remark on few common issues, The web site taste is ideal, the articles is
    in point of fact great : D. Just right task, cheers

  41. Hello I am so grateful I found your blog, I really found
    you by mistake, while I was searching on Bing for something else, Anyhow I am here now and would just like to
    say many thanks for a fantastic post and a all round thrilling blog (I also love the theme/design), I don’t have time to browse it all at the moment but I have book-marked it
    and also added your RSS feeds, so when I have time I will be back to read a lot more, Please do keep up the excellent b.

  48. I like the valuable info you provide in your articles. I’ll bookmark your blog and check again here frequently.
    I am quite certain I will learn plenty of new stuff right here!
    Good luck for the next!

  52. Hello! I know this is somewhat off topic but I
    was wondering if you knew where I could locate a captcha plugin for
    my comment form? I’m using the same blog platform as yours and
    I’m having problems finding one? Thanks a lot!

  58. Hello There. I found your weblog the use of msn. This is a
    very smartly written article. I will make sure to bookmark it and return to
    learn more of your helpful information. Thanks for the post.

    I will definitely comeback.

  59. Interesting blog! Is your theme custom made or did you download it from somewhere?
    A theme like yours with a few simple tweeks would really
    make my blog jump out. Please let me know where you got your design. Thank you

  63. Hey There. I found your blog using msn.
    This is a really well written article. I will be sure to bookmark
    it and come back to read more of your useful info.
    Thanks for the post. I will definitely return.

  66. Pretty nice post. I just stumbled upon your blog and wished to
    say that I have truly enjoyed surfing around your blog posts.
    In any case I will be subscribing to your feed and I hope you
    write again soon!

  68. Thanks , I’ve recently been searching for info about
    this topic for a long time and yours is the best I’ve discovered so far.
    However, what in regards to the conclusion? Are you positive in regards to the supply?

  73. I am extremely inspired with your writing abilities as smartly as
    with the layout to your weblog. Is that this a paid subject matter or
    did you modify it your self? Anyway keep up the excellent high
    quality writing, it is rare to look a great blog like this one today..

  74. You’ve made some decent points there. I checked on the net for more
    info about the issue and found most people will go along with your views
    on this website.

  84. With havin so much content and articles do you ever run into any issues of plagorism or copyright violation? My site has a lot
    of unique content I’ve either authored myself or outsourced but it
    looks like a lot of it is popping it up all over the web without my authorization. Do you know any
    techniques to help prevent content from being ripped
    off? I’d really appreciate it.

  88. With havin so much content and articles do you ever run into any issues of plagorism or copyright infringement?
    My site has a lot of unique content I’ve either authored myself
    or outsourced but it appears a lot of it is popping it up all over the internet without my
    agreement. Do you know any ways to help stop content from being ripped
    off? I’d genuinely appreciate it.

  92. What i do not understood is in truth how you are now not really a lot more
    neatly-preferred than you may be now. You are so intelligent.
    You realize thus considerably in the case of this matter, made me individually believe it from a lot of numerous angles.
    Its like men and women are not interested unless
    it’s one thing to do with Girl gaga! Your personal stuffs outstanding.
    All the time take care of it up!

  93. hey there and thank you for your information – I have certainly picked up anything new from right here.
    I did however expertise some technical points using this website,
    since I experienced to reload the website lots of times previous to I could get it to load properly.
    I had been wondering if your web host is OK?
    Not that I am complaining, but slow loading instances times will
    very frequently affect your placement in google and
    could damage your high quality score if advertising and marketing with
    Adwords. Anyway I’m adding this RSS to my email and can look out for a
    lot more of your respective interesting content.
    Make sure you update this again very soon.

  98. It’s perfect time to make some plans for the long run and it is time
    to be happy. I have read this submit and if I may I wish to suggest you some interesting
    issues or suggestions. Perhaps you can write subsequent articles relating to this article.
    I want to learn more issues about it!

  101. This design is wicked! You definitely know how to keep a reader entertained.

    Between your wit and your videos, I was almost moved to start my
    own blog (well, almost…HaHa!) Fantastic job. I really enjoyed
    what you had to say, and more than that, how you presented it.
    Too cool!

  103. Hello there, just became aware of your blog through Google, and found that
    it’s truly informative. I am going to watch out
    for brussels. I will be grateful if you continue this in future.

    Lots of people will be benefited from your writing. Cheers!

  106. hey there and thank you for your info – I have definitely picked up anything new from right here.
    I did however expertise several technical issues using this web site, as I experienced to reload the web site many
    times previous to I could get it to load correctly. I had been wondering if your web hosting is OK?
    Not that I’m complaining, but slow loading instances times will often affect
    your placement in google and can damage your high-quality score if ads
    and marketing with Adwords. Well I’m adding this RSS to my e-mail and can look out for much more of your respective fascinating content.
    Make sure you update this again very soon.

  107. Hi there! This post couldn’t be written any better!
    Going through this article reminds me of my previous roommate!
    He continually kept preaching about this. I most certainly will send this article to him.
    Fairly certain he’ll have a great read. Thank you for sharing!

  111. Thank you a bunch for sharing this with all people you actually recognize
    what you’re speaking about! Bookmarked. Please additionally visit my website =).
    We will have a hyperlink change contract among us

  119. Heya i’m for the first time here. I found this board and I find It truly useful &
    it helped me out much. I hope to give something back and aid others like you aided
    me.

  123. My spouse and I absolutely love your blog and find nearly all of your post’s to be exactly what I’m looking for.

    Does one offer guest writers to write content available for you?
    I wouldn’t mind writing a post or elaborating on a few of the subjects you write related to here.
    Again, awesome blog!

  136. Hi there outstanding website! Does running a blog like this require a large amount of work?
    I’ve very little understanding of coding but I was
    hoping to start my own blog soon. Anyhow, should you have any ideas or tips for new blog owners please share.
    I know this is off topic but I simply wanted to ask. Appreciate it!

  140. I think this is one of the most significant information for me.
    And i am glad reading your article. But should remark on some general things, The web site style is perfect, the articles is really great : D.
    Good job, cheers

  142. I like the helpful information you supply for your articles.

    I’ll bookmark your blog and test once more right here frequently.
    I’m fairly sure I will be informed a lot of new stuff proper right here!
    Best of luck for the next!

  151. Hey There. I found your weblog the usage of msn. This is
    an extremely well written article. I will make sure to bookmark
    it and come back to read extra of your useful information. Thank you for the post.
    I will definitely return.

  155. Hello there! I know this is kinda off topic nevertheless I’d figured I’d
    ask. Would you be interested in trading links or maybe guest
    authoring a blog article or vice-versa? My website covers
    a lot of the same topics as yours and I believe we could greatly benefit from each other.
    If you might be interested feel free to send me an email.
    I look forward to hearing from you! Terrific blog by the way!

  159. Greate post. Keep posting such kind of info on your blog.
    Im really impressed by your blog.
    Hi there, You’ve performed an incredible job.

    I will definitely digg it and individually suggest
    to my friends. I am confident they will be benefited from this website.

  161. What’s Happening i am new to this, I stumbled upon this I have found It positively helpful and
    it has helped me out loads. I hope to contribute & aid other users like its
    aided me. Good job.

  165. Hello, Neat post. There’s an issue with your site in internet explorer, could
    test this? IE nonetheless is the market chief and a large component to folks will miss your wonderful writing
    because of this problem.

  167. I blog quite often and I really appreciate your content.
    This great article has really peaked my interest.
    I am going to book mark your site and keep checking for new details about once per week.
    I opted in for your Feed as well.

  168. I’m no longer certain where you are getting your information, however great topic.
    I must spend a while learning much more or figuring out
    more. Thanks for fantastic info I was searching for this
    info for my mission.

  171. Hi, i think that i saw you visited my website so i came to “return the favor”.I am attempting
    to find things to enhance my site!I suppose its ok to use a few
    of your ideas!!

  178. Hey There. I discovered your weblog the use of msn. This is an extremely smartly written article.
    I’ll make sure to bookmark it and come back to read more of your useful information. Thanks for the post.
    I will certainly comeback.

  179. I believe what you published made a lot of sense.
    However, think on this, what if you added a little content?
    I am not saying your content is not good, but suppose you
    added a title that grabbed a person’s attention? I mean Molecule That Gives Energy-burning Brown Fat Its
    Identity Could Lead To Drugs For Obesity – Agricultural Business
    Information is kinda vanilla. You could glance at Yahoo’s home page and see
    how they create news titles to get viewers to
    open the links. You might add a related video or a pic or two to get
    readers interested about everything’ve written. In my opinion, it could make your posts a
    little livelier.

  185. Someone essentially assist to make severely articles I’d state.
    That is the very first time I frequented your web page and so far?
    I surprised with the research you made to create this actual submit extraordinary.
    Excellent process!

  186. With havin so much written content do you ever run into any
    issues of plagorism or copyright infringement?
    My site has a lot of unique content I’ve either authored myself or
    outsourced but it seems a lot of it is popping it up all over the web without my agreement.

    Do you know any ways to help protect against content from being stolen? I’d definitely appreciate it.

  187. I love your blog.. very nice colors & theme.
    Did you create this website yourself or did you hire someone to
    do it for you? Plz reply as I’m looking to design my own blog and would like to know where u got this from.
    thanks a lot

  189. My partner and I stumbled over here by a different web page and thought I might check things out.
    I like what I see so i am just following you.
    Look forward to exploring your web page repeatedly.

  190. Hi, i think that i noticed you visited my website so i came to go back the prefer?.I
    am attempting to in finding things to enhance my
    website!I guess its good enough to use some of your ideas!!

  191. hi!,I really like your writing very a lot! share
    we keep in touch more approximately your post on AOL?
    I require an expert in this house to unravel my problem.
    Maybe that is you! Looking ahead to look you.

  192. you’re really a good webmaster. The site loading pace is amazing.
    It seems that you are doing any distinctive trick.
    Moreover, The contents are masterwork. you have performed a fantastic task on this matter!

  193. Magnificent beat ! I wish to apprentice at the same time as you amend your site, how can i
    subscribe for a blog website? The account aided me a acceptable deal.
    I were tiny bit acquainted of this your broadcast offered shiny transparent concept

  199. Hey I am so happy I found your web site, I really found you by
    accident, while I was researching on Askjeeve for something else,
    Regardless I am here now and would just like
    to say kudos for a fantastic post and a all round enjoyable
    blog (I also love the theme/design), I don’t have time to look over it all at the minute but
    I have bookmarked it and also included your RSS feeds, so when I have time I will be back to read
    a great deal more, Please do keep up the fantastic b.

  200. What i don’t realize is actually how you are not actually much more neatly-favored than you might be
    right now. You are so intelligent. You understand therefore considerably
    with regards to this subject, made me for my part consider it from so many numerous angles.
    Its like women and men don’t seem to be fascinated
    except it’s one thing to do with Woman gaga! Your individual stuffs nice.
    All the time care for it up!

  204. Oh my goodness! Impressive article dude! Many thanks, However I am going
    through difficulties with your RSS. I don’t know the reason why I am unable to join it.

    Is there anyone else having similar RSS problems? Anyone who knows the answer can you kindly respond?
    Thanks!!

  211. Heya i’m for the primary time here. I came across this
    board and I find It really helpful & it helped me out a lot.
    I’m hoping to give one thing again and aid others such as you aided me.

  212. Hi there, I found your web site via Google at the same time
    as searching for a comparable matter, your web site came
    up, it appears to be like great. I have bookmarked it in my google bookmarks.

    Hi there, just become aware of your blog thru Google, and located that it is truly informative.

    I’m going to watch out for brussels. I’ll be grateful when you
    continue this in future. Lots of other people will likely
    be benefited from your writing. Cheers!

  214. Its like you read my mind! You appear to know so
    much about this, like you wrote the book in it or something.
    I think that you can do with some pics to drive the message home a bit, but other than that, this is great blog.
    An excellent read. I will definitely be back.

  216. Right here is the right webpage for everyone who hopes to find out
    about this topic. You know so much its almost tough to argue with you (not
    that I actually would want to…HaHa). You certainly put a brand new spin on a topic that has been written about for a long time.
    Great stuff, just excellent!

  218. I do accept as true with all of the concepts you’ve presented on your post.
    They’re really convincing and can definitely work.
    Still, the posts are very short for newbies. May just you
    please extend them a bit from next time? Thank you for
    the post.

  230. First of all I want to say fantastic blog! I had a quick
    question which I’d like to ask if you don’t mind. I was interested to know how
    you center yourself and clear your mind before writing.
    I’ve had a hard time clearing my thoughts in getting my ideas out there.
    I truly do enjoy writing however it just seems like the first 10 to 15 minutes tend to be wasted simply just
    trying to figure out how to begin. Any recommendations or hints?

    Many thanks!

  233. Just desire to say your article is as amazing. The clarity in your post is simply cool and i can assume you’re
    an expert on this subject. Fine with your permission allow me to grab your RSS feed
    to keep updated with forthcoming post. Thanks a million and please continue the rewarding work.

  234. You could definitely see your enthusiasm within the article you
    write. The arena hopes for even more passionate writers like you who are not afraid to
    mention how they believe. At all times go after your heart.

  235. Do you have a spam problem on this blog; I also am a blogger, and I was curious about your situation; we
    have developed some nice methods and we are looking to swap solutions
    with others, please shoot me an email if interested.

  236. I used to be suggested this web site by my cousin.
    I am not certain whether this put up is written by
    way of him as nobody else realize such special about my trouble.
    You’re amazing! Thanks!

  237. It’s the best time to make some plans for the longer term and
    it’s time to be happy. I have learn this post and if I could I wish to suggest you some fascinating issues or tips.
    Perhaps you could write next articles relating to this article.
    I wish to learn even more things approximately it!

  238. Hey There. I found your weblog the usage of msn. This is a really well written article.
    I will make sure to bookmark it and return to learn more of your helpful information. Thank you for the post.

    I’ll definitely return.

  239. Write more, thats all I have to say. Literally, it seems as though you relied on the
    video to make your point. You obviously know what youre talking about, why waste your intelligence on just posting videos to your blog when you could be
    giving us something enlightening to read?

  253. I think this is one of the most significant info for
    me. And i am glad reading your article. But want to remark on some general
    things, The site style is ideal, the articles is really excellent :
    D. Good job, cheers

  256. hello there and thank you for your info – I’ve certainly picked up something new from right here.

    I did however expertise a few technical points using this web site, as
    I experienced to reload the site many times previous to
    I could get it to load properly. I had been wondering if your
    web hosting is OK? Not that I am complaining, but slow loading instances times will very
    frequently affect your placement in google and can damage your high-quality score if advertising and marketing with Adwords.
    Anyway I am adding this RSS to my e-mail and can look out for a
    lot more of your respective interesting content. Make sure you update this again soon.

  259. I’m now not sure where you’re getting your info, however
    good topic. I must spend some time studying more or understanding more.

    Thank you for great information I used to be on the lookout for this
    information for my mission.

  263. An impressive share! I’ve just forwarded this onto a friend
    who was doing a little research on this. And he in fact bought me dinner
    simply because I discovered it for him… lol. So let me reword this….

    Thank YOU for the meal!! But yeah, thanx for
    spending time to discuss this matter here on your blog.

  269. Hi there! I know this is somewhat off topic but I was
    wondering which blog platform are you using for this website?
    I’m getting fed up of WordPress because I’ve had issues with hackers and I’m looking
    at options for another platform. I would be awesome if you could point me in the direction of a good platform.

  270. Greetings! Quick question that’s totally off topic. Do you know how to make your site mobile friendly?
    My web site looks weird when viewing from my iphone.

    I’m trying to find a template or plugin that might be able to resolve
    this problem. If you have any suggestions, please share. Thank you!

  272. It’s a pity you don’t have a donate button! I’d definitely donate
    to this excellent blog! I suppose for now i’ll settle for book-marking and adding your RSS feed
    to my Google account. I look forward to brand new updates and will talk about this blog with my Facebook group.
    Talk soon!

  274. You actually make it seem so easy with your presentation but I find this
    topic to be really something that I think I would never understand.
    It seems too complex and very broad for me.
    I am looking forward for your next post, I’ll try to get the
    hang of it!

  281. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
    You obviously know what youre talking about, why throw
    away your intelligence on just posting videos to your blog when you could be giving us
    something enlightening to read?

  290. Hi would you mind letting me know which hosting company
    you’re using? I’ve loaded your blog in 3 completely different browsers and I must say this blog loads a lot
    faster then most. Can you suggest a good hosting provider
    at a reasonable price? Many thanks, I appreciate it!

  292. Very nice post. I simply stumbled upon your blog and wanted to mention that I have truly enjoyed surfing around your blog posts.
    After all I’ll be subscribing for your rss feed and I hope you
    write once more very soon!

  297. We’re a gaggle of volunteers and opening a new scheme in our community.
    Your website offered us with helpful info to work on. You have performed a formidable process and our entire community will probably be grateful to you.

  306. Hello there! This post couldn’t be written much
    better! Going through this post reminds me of my previous roommate!
    He continually kept preaching about this. I’ll
    send this post to him. Pretty sure he will have a good read.
    Thanks for sharing!

  314. My partner and I stumbled over here coming from
    a different web page and thought I might check things out.
    I like what I see so now i am following you.
    Look forward to looking into your web page yet again.

  320. You are so awesome! I don’t think I have read a single thing like that before.
    So great to find another person with some original thoughts
    on this subject. Really.. thanks for starting this up.
    This website is something that’s needed on the internet,
    someone with some originality!

  323. Wonderful items from you, man. I have understand your stuff prior to and you’re just too excellent.
    I actually like what you have received right here, certainly like what you
    are saying and the way during which you assert
    it. You’re making it enjoyable and you still care for to keep it
    sensible. I cant wait to learn far more from you. That is
    actually a terrific website.

  324. When someone writes an piece of writing he/she retains the
    plan of a user in his/her brain that how a user can be aware of it.

    Thus that’s why this piece of writing is
    outstdanding. Thanks!

  325. Wow that was odd. I just wrote an incredibly long comment but after I clicked submit my comment
    didn’t appear. Grrrr… well I’m not writing all that over again. Anyhow, just wanted to
    say superb blog!

  326. Today, I went to the beachfront with my children. I found
    a sea shell and gave it to my 4 year old daughter and
    said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed.

    There was a hermit crab inside and it pinched her ear.
    She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

  331. It’s perfect time to make some plans for the long run and
    it is time to be happy. I’ve learn this publish and if I could I desire to
    recommend you few attention-grabbing issues or advice.

    Maybe you can write next articles relating to this article.
    I want to read more issues approximately it!

  332. This is the right site for anybody who would like to
    find out about this topic. You realize so much its almost
    hard to argue with you (not that I really will need to…HaHa).

    You certainly put a fresh spin on a subject that has been discussed
    for years. Excellent stuff, just great!

  335. I loved as much as you will receive carried out right here.
    The sketch is attractive, your authored material stylish. nonetheless, you command get bought
    an edginess over that you wish be delivering
    the following. unwell unquestionably come more formerly again since exactly the same nearly very often inside case you
    shield this hike.

  336. I’m extremely inspired together with your writing abilities
    as well as with the layout on your weblog. Is that this a
    paid subject or did you modify it your self? Anyway
    stay up the nice quality writing, it’s uncommon to look a nice blog like this
    one today..

  338. Heya just wanted to give you a brief heads up and let you know a
    few of the images aren’t loading correctly. I’m not sure why
    but I think its a linking issue. I’ve tried it in two different browsers and
    both show the same results.

  339. Appreciating the commitment you put into your website and
    in depth information you provide. It’s good to come across a blog every once in a while that isn’t the same unwanted rehashed material.
    Fantastic read! I’ve bookmarked your site and I’m adding your RSS
    feeds to my Google account.

  341. Hi there, I discovered your site by the use of Google at the same time as searching for a similar matter, your web site got here up,
    it appears good. I have bookmarked it in my google bookmarks.

    Hello there, simply become aware of your weblog thru Google, and found that it
    is really informative. I’m going to watch out for brussels.
    I will appreciate if you continue this in future. A lot of folks will likely be benefited out of your writing.
    Cheers!

  342. I’d like to thank you for the efforts you have put in penning this website.
    I really hope to check out the same high-grade
    blog posts by you later on as well. In fact, your creative writing abilities has encouraged me to get my own blog now 😉

  343. Hmm it looks like your blog ate my first comment (it was super long) so I guess
    I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog.
    I as well am an aspiring blog blogger but I’m still new to everything.
    Do you have any recommendations for newbie blog writers?
    I’d definitely appreciate it.

  344. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my
    blog that automatically tweet my newest twitter updates.

    I’ve been looking for a plug-in like this for quite some time
    and was hoping maybe you would have some experience with
    something like this. Please let me know if you run into anything.
    I truly enjoy reading your blog and I look forward to your new updates.

  345. Hi! Quick question that’s totally off topic. Do you know
    how to make your site mobile friendly? My blog looks weird when viewing from
    my apple iphone. I’m trying to find a theme or plugin that might be able to fix this problem.
    If you have any recommendations, please share. Appreciate
    it!

  348. Thanks for your personal marvelous posting! I genuinely
    enjoyed reading it, you could be a great author. I
    will be sure to bookmark your blog and definitely will come back later
    in life. I want to encourage you to ultimately continue your great posts,
    have a nice afternoon!

  357. The other day, while I was at work, my sister stole my apple ipad and tested to see if it can survive a twenty five foot drop, just so she
    can be a youtube sensation. My iPad is now broken and
    she has 83 views. I know this is totally off topic
    but I had to share it with someone!

  358. With havin so much content do you ever run into any problems of plagorism or copyright violation? My blog has a lot of completely unique content I’ve either authored myself or outsourced but it
    looks like a lot of it is popping it up
    all over the web without my agreement. Do you know any techniques to help prevent
    content from being stolen? I’d definitely appreciate it.

  359. Have you ever thought about publishing an ebook or guest authoring on other blogs?
    I have a blog centered on the same subjects you discuss
    and would love to have you share some stories/information. I know my viewers would enjoy your work.
    If you are even remotely interested, feel free to shoot me an e-mail.

  361. I was wondering if you ever considered changing the layout of your site?
    Its very well written; I love what youve got to say. But maybe you could a little more in the
    way of content so people could connect with it
    better. Youve got an awful lot of text for only having one or two pictures.
    Maybe you could space it out better?

  363. Howdy just wanted to give you a quick heads up.
    The text in your post seem to be running off the screen in Firefox.
    I’m not sure if this is a format issue or something to do with web
    browser compatibility but I thought I’d post to let you know.
    The design and style look great though! Hope you get the issue fixed soon. Thanks

  369. I think this is among the most significant information for me.
    And i’m glad reading your article. But wanna remark on few general things, The
    web site style is perfect, the articles is really great :
    D. Good job, cheers

  375. The other day, while I was at work, my sister stole my iphone and tested to see
    if it can survive a 25 foot drop, just so she can be a youtube sensation. My apple ipad is now broken and she
    has 83 views. I know this is completely off topic but
    I had to share it with someone!

  379. Excellent web site you have got here.. It’s hard to find excellent writing like yours these days.
    I honestly appreciate people like you! Take care!!

  384. Wow, superb blog format! How lengthy have you ever been blogging
    for? you make blogging glance easy. The entire
    look of your website is wonderful, let alone the content!

  385. Fantastic beat ! I wish to apprentice even as you amend your
    site, how could i subscribe for a blog web site?
    The account helped me a acceptable deal. I have been a little bit acquainted of this your broadcast
    offered bright transparent idea

  387. First of all I want to say great blog! I had a quick question in which I’d like to ask if you
    don’t mind. I was curious to know how you center yourself and clear your head
    prior to writing. I have had difficulty clearing my thoughts in getting my
    thoughts out there. I do enjoy writing but it just seems like the first 10 to
    15 minutes tend to be lost simply just trying to figure out how to begin. Any recommendations or hints?

    Kudos!

  392. I was wondering if you ever considered changing the structure of your website?
    Its very well written; I love what youve got to say. But maybe you could a little more
    in the way of content so people could connect with it better.
    Youve got an awful lot of text for only having 1 or two images.
    Maybe you could space it out better?

  394. I blog often and I genuinely thank you for your information.
    Your article has truly peaked my interest. I am going
    to book mark your site and keep checking for new details about once per week.
    I opted in for your Feed too.

  395. Hmm is anyone else experiencing problems with
    the images on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog.
    Any suggestions would be greatly appreciated.

  399. Hi there! I could have sworn I’ve been to this web site before but
    after browsing through many of the posts I realized it’s new to me.

    Anyways, I’m certainly pleased I came across it and I’ll be book-marking it
    and checking back frequently!

  400. I really like your blog.. very nice colors & theme.
    Did you make this website yourself or did you hire someone
    to do it for you? Plz reply as I’m looking to design my own blog and would like to know where u got
    this from. appreciate it

  408. Wonderful blog you have here but I was wanting to know if you
    knew of any message boards that cover the same topics talked about here?
    I’d really love to be a part of group where I can get advice from other knowledgeable individuals that share the same interest.
    If you have any suggestions, please let me know. Appreciate it!

  411. Thanks for another fantastic article. The place else may just anybody get that kind of information in such a perfect
    approach of writing? I have a presentation next week, and I am at the look for such
    information.

  413. Undeniably consider that that you said. Your favourite
    justification seemed to be at the internet the simplest thing
    to be mindful of. I say to you, I definitely get
    annoyed even as other folks think about concerns that they just do not recognise about.
    You controlled to hit the nail upon the top and also outlined out the
    entire thing with no need side effect , other folks could take a signal.
    Will likely be back to get more. Thanks

  415. Excellent beat ! I would like to apprentice while you amend your website, how can i subscribe for a blog site?
    The account helped me a applicable deal. I were tiny bit acquainted of
    this your broadcast provided bright clear concept

  416. Wonderful beat ! I would like to apprentice at the same time as you amend your web site, how can i subscribe for
    a blog website? The account aided me a acceptable deal.
    I had been tiny bit familiar of this your broadcast
    offered bright clear idea

  419. Hey! Someone in my Myspace group shared this
    site with us so I came to look it over. I’m definitely loving the information. I’m book-marking and will be
    tweeting this to my followers! Wonderful blog and wonderful style and design.

  421. Hi there would you mind sharing which blog platform you’re using?
    I’m looking to start my own blog soon but I’m
    having a difficult time choosing between BlogEngine/Wordpress/B2evolution and
    Drupal. The reason I ask is because your design seems different then most blogs and I’m looking for something completely
    unique. P.S Apologies for getting off-topic but
    I had to ask!

  422. Hi there! Someone in my Facebook group shared this website
    with us so I came to look it over. I’m definitely loving the
    information. I’m bookmarking and will be tweeting this to my followers!
    Terrific blog and great design and style.

  423. Magnificent goods from you, man. I’ve understand your stuff previous to and you are just extremely fantastic.
    I really like what you’ve acquired here, certainly
    like what you’re stating and the way in which you say it.
    You make it entertaining and you still care for to keep it wise.

    I can not wait to read much more from you. This is actually a terrific website.

  425. My spouse and I stumbled over here different web page and thought I should check things out.
    I like what I see so now i am following you. Look forward to looking at your web page yet again.

  428. Write more, thats all I have to say. Literally, it seems as
    though you relied on the video to make your point.
    You clearly know what youre talking about, why throw
    away your intelligence on just posting videos to your site when you could be giving
    us something informative to read?

LEAVE A REPLY

Please enter your comment!
Please enter your name here